Insights into how environment shapes post-mortem RNA transcription in mouse brain.

ABSTRACT: Most biological features that occur on the body after death were already deciphered by traditional medicine. However, the molecular mechanisms triggered in the cellular microenvironment are not fully comprehended yet. Previous studies reported gene expression alterations in the post-mortem condition, but little is known about how the environment could influence RNA degradation and transcriptional regulation. In this work, we analysed the transcriptome of mouse brain after death under three concealment simulations (air exposed, buried, and submerged). Our analyses identified 2,103 genes differentially expressed in all tested groups 48 h after death. Moreover, we identified 111 commonly upregulated and 497 commonly downregulated genes in mice from the concealment simulations. The gene functi

SUBMITTER: Bonadio RS 

PROVIDER: S-EPMC8217559 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature