SIRT2 promotes murine melanoma progression through natural killer cell inhibition.

ABSTRACT: SIRT2, an NAD⁺-dependent histone deacetylase, has been shown to play a pivotal role in various physiological processes, however, its role in cancer is currently controversial. In recent years, SIRT2 has been described as both a tumor suppressor and oncogene with divergent expression and function in various malignancies. Using murine allograft melanoma models, our results suggest increased systemic expression of SIRT2 promotes tumor progression. In this study, SIRT2-overexpressing mice exhibited enhanced tumor growth and larger tumor volumes compared to their wild-type littermates. Mechanistically, systemic overexpression of SIRT2 reduces the number of tumor-infiltrating natural killer (NK) cells and suppresses NK cell function and proliferation within the tumor microenvironment

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8217567 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature