Blood-Based Biomarkers: A Forgotten Friend of Hyperacute Ischemic Stroke.

ABSTRACT: Ischemic stroke (IS) is the second leading cause of death worldwide. Multimodal neuroimaging techniques that have significantly facilitated the diagnosis of hyperacute IS are not widely used in underdeveloped areas and community hospitals owing to drawbacks such as high cost and lack of trained operators. Moreover, these methods do not have sufficient resolution to detect changes in the brain at the cellular and molecular levels after IS onset. In contrast, blood-based biomarkers can reflect molecular and biochemical alterations in both normal and pathophysiologic processes including angiogenesis, metabolism, inflammation, oxidative stress, coagulation, thrombosis, glial activation, and neuronal and vascular injury, and can thus provide information complementary to findings from routine ex

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8217611 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature