AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling.

ABSTRACT: Pulmonary hypertension (PH) is a debilitating and life-threatening disease characterized by increased blood pressure within the pulmonary arteries. Adenosine monophosphate-activated protein kinase (AMPK) is a heterotrimeric serine-threonine kinase that contributes to the regulation of metabolic and redox signaling pathways. It has key roles in the regulation of cell survival and proliferation. The role of AMPK in PH is controversial because both inhibition and activation of AMPK are preventive against PH development. Some clinical studies found that metformin, the first-line antidiabetic drug and the canonical AMPK activator, has therapeutic efficacy during treatment of early-stage PH. Other study findings suggest the use of metformin is preferentially beneficial for treatment of PH associ

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8217619 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature