Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural Zimbabwe.

ABSTRACT:

Background

Preterm birth and low birth weight (LBW) affect one in ten and one in seven livebirths, respectively, primarily in low-income and middle-income countries (LMIC) and are major predictors of poor child health outcomes. However, both have been recalcitrant to public health intervention. The maternal intestinal microbiome may undergo substantial changes during pregnancy and may influence fetal and neonatal health in LMIC populations.

Methods

Within a subgroup of 207 mothers and infants enrolled in the SHINE trial in rural Zimbabwe, we performed shotgun metagenomics on 351 fecal specimens provided during pregnancy and at 1-month post-partum to investigate the relationship between the pregnancy gut microbiome and infant gestational age, birth weight, 1-month length-, an

SUBMITTER: Gough EK 

PROVIDER: S-EPMC8217692 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature