Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.

ABSTRACT: Cells of the same type can be generated by distinct cellular lineages that originate in different parts of the developing embryo ('lineage convergence'). Several Caenorhabditis elegans neuron classes composed of left/right or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan-neuronal markers and terminal selector-type transcription factors that confer neuron class-specific features. Another basic helix-loop-helix (bHLH) gene, the Achaete-Scute homolog hlh-14, is expressed in a mirror image pattern relative to lin-32 and is required to in

SUBMITTER: Masoudi N 

PROVIDER: S-EPMC8217713 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature