The Multiple Roles of B Cells in the Pathogenesis of Sjogren's Syndrome.

ABSTRACT: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration and tissue destruction of exocrine glands such as salivary glands. Although the formation of ectopic lymphoid tissue in exocrine glands and overproduction of autoantibodies by autoreactive B cells highlight the critical involvement of B cells in disease development, the precise roles of various B cell subsets in pSS pathogenesis remain partially understood. Current studies have identified several novel B cell subsets with multiple functions in pSS, among which autoreactive age-associated B cells, and plasma cells with augmented autoantibody production contribute to the disease progression. In addition, tissue-resident Fc Receptor-Like 4 (FcRL4)⁺ B cell subset with enhanced

SUBMITTER: Du W 

PROVIDER: S-EPMC8217880 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature