SLC15A4 Serves as a Novel Prognostic Biomarker and Target for Lung Adenocarcinoma.

ABSTRACT:

Background

SLC15A family members are known as electrogenic transporters that take up peptides into cells through the proton-motive force. Accumulating evidence indicates that aberrant expression of SLC15A family members may play crucial roles in tumorigenesis and tumor progression in various cancers, as they participate in tumor metabolism. However, the exact prognostic role of each member of the SLC15A family in human lung cancer has not yet been elucidated.

Materials and methods

We investigated the SLC15A family members in lung cancer through accumulated data from TCGA and other available online databases by integrated bioinformatics analysis to reveal the prognostic value, potential clinical application and underlying molecular mechanisms of SLC15A family members in lung

SUBMITTER: Huang H 

PROVIDER: S-EPMC8217884 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature