Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults.

ABSTRACT: Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding

SUBMITTER: Vikner T 

PROVIDER: S-EPMC8217890 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature