Methodological framework for radiomics applications in Hodgkin's lymphoma.

ABSTRACT:

Background

According to published data, radiomics features differ between lesions of refractory/relapsing HL patients from those of long-term responders. However, several methodological aspects have not been elucidated yet.

Purpose

The study aimed at setting up a methodological framework in radiomics applications in Hodgkin's lymphoma (HL), especially at (a) developing a novel feature selection approach, (b) evaluating radiomic intra-patient lesions' similarity, and (c) classifying relapsing refractory (R/R) vs non-(R/R) patients.

Methods

We retrospectively included 85 patients (male:female = 52:33; median age 35 years, range 19-74). LIFEx (www.lifexsoft.org) was used for [¹⁸F]FDG-PET/CT segmentation and feature extraction. Features were a-priori selected i

SUBMITTER: Sollini M 

PROVIDER: S-EPMC8218114 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature