⁶⁸Ga-DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas.

ABSTRACT:

Purpose

Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express somatostatin receptors (SSTR), but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and ¹¹¹In-DTPA-octreotide scintigraphy in vivo. The aim of this study was to assess SSTR expression in NFMA in vivo using ⁶⁸Ga-DOTATATE PET, which offers superior sensitivity and spatial resolution as compared with planar scintigraphy or SPECT.

Methods

Thirty-seven patients diagnosed with NFMA underwent ⁶⁸Ga-DOTATATE PET/CT of the head in the framework of a randomised controlled trial assessing the effect of the somatostatin analog

SUBMITTER: Boertien TM 

PROVIDER: S-EPMC8218160 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature