ModFOLD8: accurate global and local quality estimates for 3D protein models.

ABSTRACT: Methods for estimating the quality of 3D models of proteins are vital tools for driving the acceptance and utility of predicted tertiary structures by the wider bioscience community. Here we describe the significant major updates to ModFOLD, which has maintained its position as a leading server for the prediction of global and local quality of 3D protein models, over the past decade (>20 000 unique external users). ModFOLD8 is the latest version of the server, which combines the strengths of multiple pure-single and quasi-single model methods. Improvements have been made to the web server interface and there has been successive increases in prediction accuracy, which were achieved through integration of newly developed scoring methods and advanced deep learning-based residue contact predic

SUBMITTER: McGuffin LJ 

PROVIDER: S-EPMC8218196 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature