DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal.

ABSTRACT: Combinatorial therapies that target multiple pathways have shown great promises for treating complex diseases. DrugComb (https://drugcomb.org/) is a web-based portal for the deposition and analysis of drug combination screening datasets. Since its first release, DrugComb has received continuous updates on the coverage of data resources, as well as on the functionality of the web server to improve the analysis, visualization and interpretation of drug combination screens. Here, we report significant updates of DrugComb, including: (i) manual curation and harmonization of more comprehensive drug combination and monotherapy screening data, not only for cancers but also for other diseases such as malaria and COVID-19; (ii) enhanced algorithms for assessing the sensitivity and synergy of drug c

SUBMITTER: Zheng S 

PROVIDER: S-EPMC8218202 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature