Mapping mechanical properties of biological materials via an add-on Brillouin module to confocal microscopes.

ABSTRACT: Several techniques have been developed over the past few decades to assess the mechanical properties of biological samples, which has fueled a rapid growth in the fields of biophysics, bioengineering, and mechanobiology. In this context, Brillouin optical spectroscopy has long been known as an intriguing modality for noncontact material characterization. However, limited by speed and sample damage, it had not translated into a viable imaging modality for biomedically relevant materials. Recently, based on a novel spectroscopy strategy that substantially improves the speed of Brillouin measurement, confocal Brillouin microscopy has emerged as a unique complementary tool to traditional methods as it allows noncontact, nonperturbative, label-free measurements of material mechanical properties

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8218248 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature