Contribution of a Blood-Based Protein Biomarker Panel to the Classification of Indeterminate Pulmonary Nodules.

ABSTRACT:

Rationale

The workup and longitudinal monitoring for subjects presenting with pulmonary nodules is a pressing clinical problem. A blood-based biomarker panel potentially has utility for identifying subjects at higher risk for harboring a malignant nodule for whom additional workup would be indicated or subjects at reduced risk for whom imaging-based follow-up would be indicated.

Objectives

To assess whether a previously described four-protein biomarker panel, reported to improve assessment of lung cancer risk compared with a smoking-based lung cancer risk model, can provide discrimination between benign and malignant indeterminate pulmonary nodules.

Methods

A previously validated multiplex enzyme-linked immunoassay was performed on matched case and control samples fro

SUBMITTER: Ostrin EJ 

PROVIDER: S-EPMC8218328 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature