Oncogenic tuftelin 1 as a potential molecular-targeted for inhibiting hepatocellular carcinoma growth.

ABSTRACT:

Background

Abnormal tuftelin 1 (TUFT1) has been reported in multiple cancers and exhibits oncogenic roles in tumor progression. However, limited data are available on the relationship between TUFT1 and hepatocellular carcinoma (HCC), and the exact biological mechanism of TUFT1 is still poorly understood in HCC.

Aim

To investigate TUFT1 expression in HCC and how interfering TUFT1 transcription affects HCC growth.

Methods

TUFT1 in HCC and non-HCC tissues based on databases of the Cancer Genome Atlas and Oncomine were analyzed, and TUFT1 in human HCC tissues on microarray were detected by immunohistochemistry for clinicopathological features, overall survival, and disease-free survival. HCC cells were transfected with constructed vectors of TUFT1 that inter

SUBMITTER: Wu MN 

PROVIDER: S-EPMC8218352 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature