Mechanisms of reduced peak oxygen consumption in subjects with uncomplicated type 2 diabetes.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2D) increases the risk of incident heart failure (HF), whose earliest fingerprint is effort intolerance (i.e. impaired peak oxygen consumption, or VO_2peak). In the uncomplicated T2D population, however, the prevalence of effort intolerance and the underpinning mechanistic bases are uncertain. Leveraging the multiparametric characterization allowed by imaging-cardiopulmonary exercise testing (iCPET), the aim of this study is to quantify effort intolerance in T2D and to dissect the associated cardiopulmonary alterations.

Methods

Eighty-eight adults with well-controlled and uncomplicated T2D and no criteria for HF underwent a maximal iCPET with speckle tracking echocardiography, vascular and endothelial function assessment, as we

SUBMITTER: Nesti L 

PROVIDER: S-EPMC8218418 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature