Dataset Information

The adaptive benefit of evolved increases in hemoglobin-O₂ affinity is contingent on tissue O₂ diffusing capacity in high-altitude deer mice.

ABSTRACT:

Background

Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We examined how functional interactions between cardiorespiratory traits contribute to adaptive increases in the capacity for aerobic thermogenesis (maximal O₂ consumption, V̇O₂max, during acute cold exposure) in high-altitude deer mice (Peromyscus maniculatus). We crossed highland and lowland deer mice to produce F₂ inter-population hybrids, which expressed genetically based variation in hemoglobin (Hb) O₂ affinity on a mixed genetic background. We then combined physiological experiments and mathematical modeling of th

SUBMITTER: Wearing OH

PROVIDER: S-EPMC8218429 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

The adaptive benefit of evolved increases in hemoglobin-O₂ affinity is contingent on tissue O₂ diffusing capacity in high-altitude deer mice.

Background

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice.

Background

OmicsDI is part of the ELIXIR infrastructure

Tweets

The adaptive benefit of evolved increases in hemoglobin-O₂ affinity is contingent on tissue O₂ diffusing capacity in high-altitude deer mice.