Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering.

ABSTRACT: Bone tissue engineering (TE) has the potential to transform the treatment of challenging musculoskeletal pathologies. To date, clinical translation of many traditional TE strategies has been impaired by poor vascularisation of the implant. Addressing such challenges has motivated research into developmentally inspired TE strategies, whereby implants mimicking earlier stages of a tissue's development are engineered in vitro and then implanted in vivo to fully mature into the adult tissue. The goal of this study was to engineer in vitro tissues mimicking the immediate developmental precursor to long bones, specifically a vascularised hypertrophic cartilage template, and to then assess the capacity of such a construct to support endochondral bone formation in vivo.

SUBMITTER: Nulty J 

PROVIDER: S-EPMC8218548 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature