Pericardial Fat and the Risk of Heart Failure.

ABSTRACT:

Background

Obesity is a well-established risk factor for heart failure (HF). However, implications of pericardial fat on incident HF is unclear.

Objectives

This study sought to examine the association between pericardial fat volume (PFV) and newly diagnosed HF.

Methods

This study ascertained PFV using cardiac computed tomography in 6,785 participants (3,584 women and 3,201 men) without pre-existing cardiovascular disease from the MESA (Multi-Ethnic Study of Atherosclerosis). Cox proportional hazards regression was used to evaluate PFV as continuous and dichotomous variable, maximizing the J-statistic: (Sensitivity + Specificity - 1).

Results

In 90,686 person-years (median: 15.7 years; interquartile range: 11.7 to 16.5 years), 385 participants (5.7%; 164 women a

SUBMITTER: Kenchaiah S 

PROVIDER: S-EPMC8218602 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature