Unknown

Dataset Information

0

Characterization of TMexCD3-TOprJ3, an RND-Type Efflux System Conferring Resistance to Tigecycline in Proteus mirabilis, and Its Associated Integrative Conjugative Element.


ABSTRACT: The emergence and transmission of novel antimicrobial resistance genes pose a great threat to public health globally. Recently, the plasmid-encoding RND efflux pump TMexCD1-TOprJ1 in Klebsiella pneumoniae was reported to reduce the sensitivity of multiple antimicrobials. Here, we identified a pandrug-resistant Proteus mirabilis isolate that harbored the novel tmexCD3-toprJ3 gene cluster located on SXT/R391 ICE. This study expands current knowledge of the transfer mechanisms of tmexCD1-toprJ1-like gene clusters among P. mirabilis isolates and warrants further genomic epidemiology investigations.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8218640 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Characterization of TMexCD3-TOprJ3, an RND-Type Efflux System Conferring Resistance to Tigecycline in Proteus mirabilis, and Its Associated Integrative Conjugative Element.

Wang Qian Q   Peng Kai K   Liu Yuan Y   Xiao Xia X   Wang Zhiqiang Z   Li Ruichao R  

Antimicrobial agents and chemotherapy 20210617 7


The emergence and transmission of novel antimicrobial resistance genes pose a great threat to public health globally. Recently, the plasmid-encoding RND efflux pump TMexCD1-TOprJ1 in Klebsiella pneumoniae was reported to reduce the sensitivity of multiple antimicrobials. Here, we identified a pandrug-resistant Proteus mirabilis isolate that harbored the novel <i>tmexCD3-toprJ3</i> gene cluster located on SXT/R391 ICE. This study expands current knowledge of the transfer mechanisms of <i>tmexCD1-  ...[more]

Similar Datasets

| S-EPMC10654056 | biostudies-literature
| S-EPMC151746 | biostudies-literature
| S-EPMC7606855 | biostudies-literature
| S-EPMC8386438 | biostudies-literature
| S-EPMC4775944 | biostudies-literature
| S-EPMC11278526 | biostudies-literature
| S-EPMC2934980 | biostudies-literature
| S-EPMC9677350 | biostudies-literature
| S-EPMC5610337 | biostudies-literature
| S-EPMC4750665 | biostudies-literature