Glomerular Hyperfiltration Is Associated with Liver Disease Severity in Children with Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Objectives

To determine the prevalence of renal impairment in a large cohort of youths with histologically confirmed nonalcoholic fatty liver disease (NAFLD), and to determine its association with liver disease severity.

Study design

Clinical, laboratory, and histology data were collected retrospectively in a pediatric cohort with biopsy-confirmed NAFLD at a tertiary care center between 2010 and 2017. Histological NAFLD severity was scored using validated criteria. Glomerular filtration rate (GFR) was calculated and categorized as low (<90 mL/min/1.73 m²), normal (90-136 mL/min/1.73 m²), or high (>136 mL/min/1.73 m²). Univariate and multivariate modeling were used to determine differences between the GFR groups and to control for confounders.

SUBMITTER: Yodoshi T 

PROVIDER: S-EPMC8218655 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature