Staphylococcus saprophyticus Causing Infections in Humans Is Associated with High Resistance to Heavy Metals.

ABSTRACT: Staphylococcus saprophyticus is a common pathogen of the urinary tract, a heavy metal-rich environment, but information regarding its heavy metal resistance is unknown. We investigated 422 S. saprophyticus isolates from human infection and colonization/contamination, animals, and environmental sources for resistance to copper, zinc, arsenic, and cadmium using the agar dilution method. To identify the genes associated with metal resistance and assess possible links to pathogenicity, we accessed the whole-genome sequence of all isolates and used in silico and pangenome-wide association approaches. The MIC values for copper and zinc were uniformly high (1,600 mg/liter). Genes encoding copper efflux pumps (copA, copB, copZ, mco, and csoR) and zinc transporters (zinT, cz

SUBMITTER: Lawal OU 

PROVIDER: S-EPMC8218656 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature