Elementwise approach for simulating transcranial MRI-guided focused ultrasound thermal ablation.

ABSTRACT: This work explored an elementwise approach to model transcranial MRI-guided focused ultrasound (TcMRgFUS) thermal ablation, a noninvasive approach to neurosurgery. Each element of the phased array transducer was simulated individually and could be simultaneously loaded into computer memory, allowing for rapid (~2.5 s) calculation of the pressure field for different phase offsets used for beam steering and aberration correction. We simulated the pressure distribution for 431 sonications in 32 patients, applied the phase and magnitude values used during treatment, and estimated the resulting temperature rise. We systematically varied the relationship between CT (computerized tomography)-derived skull density and the acoustic attenuation and sound speed to obtain the best agreement between th

SUBMITTER: McDannold N 

PROVIDER: S-EPMC8218657 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature