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Efficacy of Omadacycline against Escherichia coli in a Mouse Urinary Tract Infection Model.

ABSTRACT: In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains.

SUBMITTER: Singh KV

PROVIDER: S-EPMC8218671 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Efficacy of Omadacycline against Escherichia coli in a Mouse Urinary Tract Infection Model.

Singh Kavindra V KV Murray Barbara E BE

Antimicrobial agents and chemotherapy 20210617 7

In a mouse urinary tract infection model, omadacycline (OMC) was comparable to gentamicin and better than ciprofloxacin (CIP) against a tetracycline-susceptible (TET-S), CIP-resistant (CIP-R) Escherichia coli strain. Gentamicin showed better efficacy than OMC against a TET-R, CIP-R E. coli strain, and OMC again showed better efficacy than CIP against this strain. OMC may warrant further study as a potential option for urinary tract infection treatment against CIP-R E. coli strains. ...[more]

PMID: 33972239

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