Nasal chondromesenchymal hamartomas in a cohort with pathogenic germline variation in DICER1.

ABSTRACT:

Background

Nasal chondromesenchymal hamartomas are benign, rare nasal tumors associated with DICER1 pathogenic germline variation. They can be locally destructive and recurrent if not completely resected.

Methodology

In this single-center, case-control study, otorhinolaryngology evaluations and review of systems questionnaires of DICER1-carriers and controls enrolled in the DICER1 Natural History Study at the National Cancer Institute were collected. Review of these medical records were analyzed to determine if DICER1-carriers experienced different sinonasal clinical manifestations compared to controls. Additionally, the number of diagnoses of nasal chondromesenchymal hamartoma cases in the NCI DICER1 study was compared against the total pe

SUBMITTER: Vasta LM 

PROVIDER: S-EPMC8218780 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature