M⁶A RNA Methylation Regulators Elicit Malignant Progression and Predict Clinical Outcome in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and N6-methyladenosine (m⁶A) is a predominant internal modification of RNA in various cancers. We obtained the expression profiles of m⁶A-related genes for HCC patients from the International Cancer Genome Consortium and The Cancer Genome Atlas datasets. Most of the m⁶A RNA methylation regulators were confirmed to be differentially expressed among groups stratified by clinical characteristics and tissues. The clinical factors (including stage, grade, and gender) were correlated with the two subgroups (cluster 1/2). We identified an m⁶A RNA methylation regulator-based signature (including METTL3, YTHDC2, and YTHDF2) that could effectively stratify a high-risk subs

SUBMITTER: Li W 

PROVIDER: S-EPMC8218914 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature