Validation of Bioavailability-Based Toxicity Models for Metals.

ABSTRACT: Regulatory jurisdictions worldwide are increasingly incorporating bioavailability-based toxicity models into development of protective values (PVALs) for freshwater and saltwater aquatic life (e.g., water quality criteria, standards, and/or guidelines) for metals. Use of such models for regulatory purposes should be contingent on their ability to meet performance criteria as specified through a model-validation process. Model validation generally involves an assessment of a model's appropriateness, relevance, and accuracy. We review existing guidance for validation of bioavailability-based toxicity models, recommend questions that should be addressed in model-validation studies, discuss model study type and design considerations, present several new ways to evaluate model performance in va

SUBMITTER: Garman ER 

PROVIDER: S-EPMC8218924 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature