LOG-CONTRAST REGRESSION WITH FUNCTIONAL COMPOSITIONAL PREDICTORS: LINKING PRETERM INFANT'S GUT MICROBIOME TRAJECTORIES TO NEUROBEHAVIORAL OUTCOME.

ABSTRACT: The neonatal intensive care unit (NICU) experience is known to be one of the most crucial factors that drive preterm infant's neurodevelopmental and health outcome. It is hypothesized that stressful early life experience of very preterm neonate is imprinting gut microbiome by the regulation of the so-called brain-gut axis, and consequently, certain microbiome markers are predictive of later infant neurodevelopment. To investigate, a preterm infant study was conducted; infant fecal samples were collected during the infants' first month of postnatal age, resulting in functional compositional microbiome data, and neurobehavioral outcomes were measured when infants reached 36-38 weeks of post-menstrual age. To identify potential microbiome markers and estimate how the trajectories of gut micro

SUBMITTER: Sun Z 

PROVIDER: S-EPMC8218926 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature