Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow.

ABSTRACT: Gold-based nanostructures with tunable wavelength of localized surface plasmon resonance (LSPR) in the second near-infrared (NIR-II) biowindow receive increasing attention in phototheranostics. In view of limited progress on NIR-II gold nanostructures, a particular liposome template-guided route is explored to synthesize novel gold nanoframeworks (AuNFs) with large mesopores (≈40 nm) for multimodal imaging along with therapeutic robustness. The synthesized AuNFs exhibit strong absorbance in NIR-II region, affording their capacity of NIR-II photothermal therapy (PTT) and photoacoustic (PA) imaging for deep tumors. Functionalization of AuNFs with hyaluronic acid (HA) endows the targeting capacity for CD44-overexpressed tumor cells while gatekeeping doxorubicin (DOX) loaded into mesopores. Co

SUBMITTER: Wang J 

PROVIDER: S-EPMC8218930 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature