FINER: enhancing the prediction of tissue-specific functions of isoforms by refining isoform interaction networks.

ABSTRACT: Annotating the functions of gene products is a mainstay in biology. A variety of databases have been established to record functional knowledge at the gene level. However, functional annotations at the isoform resolution are in great demand in many biological applications. Although critical information in biological processes such as protein-protein interactions (PPIs) is often used to study gene functions, it does not directly help differentiate the functions of isoforms, as the 'proteins' in the existing PPIs generally refer to 'genes'. On the other hand, the prediction of isoform functions and prediction of isoform-isoform interactions, though inherently intertwined, have so far been treated as independent computational problems in the literature. Here, we present FINER, a unified frame

SUBMITTER: Chen H 

PROVIDER: S-EPMC8219044 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature