Evaluation of Tissue-Level Brain Injury Metrics Using Species-Specific Simulations.

ABSTRACT: Traumatic brain injury (TBI) is a significant public health burden, and the development of advanced countermeasures to mitigate and prevent these injuries during automotive, sports, and military impact events requires an understanding of the intracranial mechanisms related to TBI. In this study, the efficacy of tissue-level injury metrics for predicting TBI was evaluated using finite element reconstructions from a comprehensive, multi-species TBI database. The database consisted of human volunteer tests, laboratory-reconstructed head impacts from sports, in vivo non-human primate (NHP) tests, and in vivo pig tests. Eight tissue-level metrics related to brain tissue strain, axonal strain, and strain-rate were evaluated using survival analysis for predicting mild and severe TBI

SUBMITTER: Wu T 

PROVIDER: S-EPMC8219195 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature