Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.

ABSTRACT: Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the modulation of the activity of specific hippocampal neuronal populations through genetic or optogenetic techniques. Here, we evaluate a strategy in which optogenetic activation of medial septal GABAergic neurons, which provide extensive projections throughout the hippocampus, is used to control seizures. We utilized the chronic intrahippocampal kainate mouse model of temporal lobe epilepsy, which results in spontaneous seizures and as is often the case in human patients, presents with hippocampal sclerosis. Medial septal GABAergic neuron populations were immunohistochemically labelled and were not reduced in epileptic conditions. Genetic label

SUBMITTER: Hristova K 

PROVIDER: S-EPMC8219369 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature