BMP signalling is required for extra-embryonic ectoderm development during pre-to-post-implantation transition of the mouse embryo.

ABSTRACT: At implantation, the mouse embryo undergoes a critical transformation which requires the precise spatiotemporal control of signalling pathways necessary for morphogenesis and developmental progression. The role played by such signalling pathways during this transition are largely unexplored, due to the inaccessibility of the embryo during the implantation when it becomes engulfed by uterine tissues. Genetic studies demonstrate that mutant embryos for BMPs die around gastrulation. Here we have aimed to dissect the role of BMPs during pre-to post-implantation transition by using a protocol permitting the development of the embryo beyond implantation stages in vitro and using stem cells to mimic post-implantation tissue organisation. By assessing both the canonical and non-canonical mechanism

SUBMITTER: Sozen B 

PROVIDER: S-EPMC8219371 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature