Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites.

ABSTRACT:

Background

The role of race/ethnicity in genetic predisposition of early-onset cancers can be estimated by comparing family-based cancer concordance rates among ethnic groups.

Methods

We used linked California health registries to evaluate the relative cancer risks for first-degree relatives of patients diagnosed between ages 0 and 26, and the relative risks of developing distinct second primary malignancies (SPMs). From 1989 to 2015, we identified 29,631 cancer patients and 62,863 healthy family members. We calculated the standardized incident ratios (SIRs) of early-onset primary cancers diagnosed in proband siblings and mothers, as well as SPMs detected among early-onset patients. Analyses were stratified by self-identified race/ethnicity.

Results

Given probands wit

SUBMITTER: Feng Q 

PROVIDER: S-EPMC8219377 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature