Erythropoietin Improves Poor Outcomes in Preterm Infants with Intraventricular Hemorrhage.

ABSTRACT:

Background

Intraventricular hemorrhage (IVH) is a common complication in preterm infants that has poor outcomes, especially in severe cases, and there are currently no widely accepted effective treatments. Erythropoietin has been shown to be neuroprotective in neonatal brain injury.

Objective

The objective of this study was to evaluate the protective effect of repeated low-dose recombinant human erythropoietin (rhEPO) in preterm infants with IVH.

Methods

This was a single-blinded prospective randomized controlled trial. Preterm infants ≤ 32 weeks gestational age who were diagnosed with IVH within 72 h after birth were randomized to receive rhEPO 500 IU/kg or placebo (equivalent volume of saline) every other day for 2 weeks. The primary outcome was death or neurologica

SUBMITTER: Song J 

PROVIDER: S-EPMC8219571 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature