Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design.

ABSTRACT: Obsessive-compulsive disorder (OCD), a leading cause of disability, affects ~1-2% of the population, and can be distressing and disabling. About 1/3 of individuals demonstrate poor responsiveness to conventional treatments. A small proportion of these individuals may be deep brain stimulation (DBS) candidates. Candidacy is assessed through a multidisciplinary process including assessment of illness severity, chronicity, and functional impact. Optimization failure, despite multiple treatments, is critical during screening. Few patients nationwide are eligible for OCD DBS and thus a multi-center approach was necessary to obtain adequate sample size. The study was conducted over a six-year period and was a NIH-funded, eight-center sham-controlled trial of DBS targeting the ventral capsule/ven

SUBMITTER: McLaughlin NCR 

PROVIDER: S-EPMC8219641 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature