Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation.

ABSTRACT: Hippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta accelerat

SUBMITTER: de Almeida-Filho DG 

PROVIDER: S-EPMC8219679 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature