Mobile element insertions and associated structural variants in longitudinal breast cancer samples.

ABSTRACT: While mobile elements are largely inactive in healthy somatic tissues, increased activity has been found in cancer tissues, with significant variation among different cancer types. In addition to insertion events, mobile elements have also been found to mediate many structural variation events in the genome. Here, to better understand the timing and impact of mobile element insertions and associated structural variants in cancer, we examined their activity in longitudinal samples of four metastatic breast cancer patients. We identified 11 mobile element insertions or associated structural variants and found that the majority of these occurred early in tumor progression. Most of the variants impact intergenic regions; however, we identified a translocation interrupting MAP2K4 involving Alu

SUBMITTER: Steely CJ 

PROVIDER: S-EPMC8219704 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature