Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918.
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ABSTRACT:
SUBMITTER: Stott LA
PROVIDER: S-EPMC8219759 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918.
Stott Lisa A LA Brighton Cheryl A CA Brown Jason J Mould Richard R Bennett Kirstie A KA Newman Robert R Currinn Heather H Autore Flavia F Higueruelo Alicia P AP Tehan Benjamin G BG MacSweeney Cliona C O'Brien Michael A MA Watson Steve P SP
Heliyon 20210601 6
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy. ...[more]
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