From Genome to Drugs: New Approaches in Antimicrobial Discovery.

ABSTRACT: Decades of successful use of antibiotics is currently challenged by the emergence of increasingly resistant bacterial strains. Novel drugs are urgently required but, in a scenario where private investment in the development of new antimicrobials is declining, efforts to combat drug-resistant infections become a worldwide public health problem. Reasons behind unsuccessful new antimicrobial development projects range from inadequate selection of the molecular targets to a lack of innovation. In this context, increasingly available omics data for multiple pathogens has created new drug discovery and development opportunities to fight infectious diseases. Identification of an appropriate molecular target is currently accepted as a critical step of the drug discovery process. Here, we review ho

SUBMITTER: Serral F 

PROVIDER: S-EPMC8219968 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature