Identification of lenvatinib prognostic index via recursive partitioning analysis in advanced hepatocellular carcinoma.

ABSTRACT:

Background

After the advent of new treatment options for advanced hepatocellular carcinoma (HCC), the identification of prognostic factors is crucial for the selection of the most appropriate therapy for each patient.

Patients and methods

With the aim to fill this gap, we applied recursive partitioning analysis (RPA) to a cohort of 404 patients treated with lenvatinib.

Results

The application of RPA resulted in a classification based on five variables that originated a new prognostic score, the lenvatinib prognostic index (LEP) index, identifying three groups: low risk [patients with prognostic nutritional index (PNI) >43.3 and previous trans-arterial chemoembolization (TACE)]; medium risk [patients with PNI >43.3 but without previous TACE and patients with PNI <43.3,

SUBMITTER: Rapposelli IG 

PROVIDER: S-EPMC8219999 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature