Homogeneous grey matter patterns in patients with obsessive-compulsive disorder.

ABSTRACT:

Background

Changes in grey matter volume have frequently been reported in patients with obsessive-compulsive disorder (OCD). Most studies performed whole brain or region-of-interest based analyses whereas grey matter volume based on structural covariance networks has barely been investigated up to now. Therefore, the present study investigated grey matter volume within structural covariance networks in a sample of 228 participants (n = 117 OCD patients, n = 111 healthy controls).

Methods

First, an independent component analysis (ICA) was performed on all subjects' preprocessed T1 images to derive covariance-dependent morphometric networks. Then, grey matter volume from each of the ICA-derived morphometric networks was extracted and compared between the groups. In addition, w

SUBMITTER: Koch K 

PROVIDER: S-EPMC8220095 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature