Topological analysis of differential effects of ketamine and propofol anaesthesia on brain dynamics.

ABSTRACT: Research has found that the vividness of conscious experience is related to brain dynamics. Despite both being anaesthetics, propofol and ketamine produce different subjective states: we explore the different effects of these two anaesthetics on the structure of dynamic attractors reconstructed from electrophysiological activity recorded from cerebral cortex of two macaques. We used two methods: the first embeds the recordings in a continuous high-dimensional manifold on which we use topological data analysis to infer the presence of higher-order dynamics. The second reconstruction, an ordinal partition network embedding, allows us to create a discrete state-transition network, which is amenable to information-theoretic analysis and contains rich information about state-transition dynamics

SUBMITTER: Varley TF 

PROVIDER: S-EPMC8220281 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature