Diabetes and Prostate Cancer Outcomes in Obese and Nonobese Men After Radical Prostatectomy.

ABSTRACT:

Background

The link between diabetes and prostate cancer progression is poorly understood and complicated by obesity. We investigated associations between diabetes and prostate cancer-specific mortality (PCSM), castrate-resistant prostate cancer (CRPC), and metastases in obese and nonobese men undergoing radical prostatectomy (RP).

Methods

We included 4688 men from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing RP from 1988 to 2017. Diabetes prior to RP, anthropometric, and clinical data were abstracted from 6 Veterans Affairs Medical Centers electronic medical records. Primary and secondary outcomes were PCSM and metastases and CRPC, respectively. Multivariable-adjusted hazard ratios (adj-HRs) and 95% confidence intervals (CIs) were estimated for

SUBMITTER: Kelkar S 

PROVIDER: S-EPMC8220304 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature