The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations.

ABSTRACT:

Background

The invasion of the red blood cells by Plasmodium falciparum merozoites involves the interplay of several proteins that are also targets for vaccine development. The proteins PfRh5-PfRipr-PfCyRPA-Pfp113 assemble into a complex at the apical end of the merozoite and are together essential for erythrocyte invasion. They have also been shown to induce neutralizing antibodies and appear to be less polymorphic than other invasion-associated proteins, making them high priority blood-stage vaccine candidates. Using available whole genome sequencing data (WGS) and new capillary sequencing data (CS), this study describes the genetic polymorphism in the Rh5 complex in P. falciparum isolates obtained from Kilifi, Kenya.

Methods

162 samples collected in 2013 and 2014 were gen

SUBMITTER: Ndwiga L 

PROVIDER: S-EPMC8220363 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature