Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis.

ABSTRACT:

Background

The choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in CF requires further evaluation. This is an update of a previously published review.

Objectives

To assess the effectiveness of single compared to combination intravenous anti-pseudomonal antibiotic therapy for treating people with CF.

Search metho

SUBMITTER: Holland P 

PROVIDER: S-EPMC8220369 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature