The redox-senescence axis and its therapeutic targeting.

ABSTRACT:

Significance

Cellular growth arrest, associated with 'senescence', helps to safeguard against the accumulation of DNA damage which is often recognized as the underlying mechanism of a wide variety of age-related pathologies including cancer. Cellular senescence has also been described as a 'double-edged sword'. In cancer, for example, the creation of an immune-suppressive milieu by senescent tumor cells through the senescence-associated secretory phenotype contributes toward carcinogenesis and cancer progression.

Recent advances

The potential for cellular senescence to confer multi-faceted effects on tissue fate has led to a rejuvenated interest in its landscape and targeting. Interestingly, redox pathways have been described as both triggers and propagators of cellular sene

SUBMITTER: Ngoi NY 

PROVIDER: S-EPMC8220395 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature