Risk of dementia in gout and hyperuricaemia: a meta-analysis of cohort studies.

ABSTRACT:

Objectives

Gout, characterised by hyperuricaemia with monosodium urate crystal formation and inflammation, is the most common inflammatory arthritis in adults. Recent studies have found that elevated uric acid levels are related to the occurrence of dementia. We conducted a study to investigate the association between dementia and gout or hyperuricaemia.

Design

Systematic review and meta-analysis of cohort studies.

Data sources

Studies were screened from inception to 28 June 2019 by searching Medline, Embase and the Cochrane Library databases.

Eligibility criteria

Cohort studies comparing the risk of dementia in patients with gout and hyperuricaemia versus non-gout and non-hyperuricaemia controls were enrolled.

Data extraction and analysis

Two reviewers

SUBMITTER: Pan SY 

PROVIDER: S-EPMC8220455 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature