Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.

ABSTRACT:

Background

Due to the molecular mechanism complexity and heterogeneity of gastric cancer (GC), mechanistically interpretable biomarkers were required for predicting prognosis and discovering therapeutic targets for GC patients.

Methods

Based on a total of 824 GC-specific fitness genes from the Project Score database, LASSOCox regression was performed in TCGA-STAD cohort to construct a GC Prognostic (GCP) model which was then evaluated on 7 independent GC datasets. Targets prioritization was performed in GC organoids. ARGLU1 was selected to further explore the biological function and molecular mechanism. We evaluated the potential of ARGLU1 serving as a promising therapeutic target for GC using patients derived xenograft (PDX) model.

Findings

The 9-gene GCP model showe

SUBMITTER: Li F 

PROVIDER: S-EPMC8220577 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature